Israeli strikes on Sunday killed the chief of Iran's armed forces intelligence unit, Mohammed Kazemi.
He was one of three intelligence generals killed by Israel in the past day, Iranian media confirmed on Sunday.
At total of 224 people have been killed in Israeli strikes since Friday, Iran's health ministry said late on Sunday, while more than 1,200 have been injured.
Some 90% of these are civilians, the health ministry said.
In Israel, the country’s total death toll rose to 13 as of late Sunday.
Explosions were heard over Tel Aviv and Jerusalem Sunday evening as Israel's Iron Dome shot down missiles fired from Iran.
Meanwhile, US President Donald Trump has said that it was possible the United States could get involved in the conflict between Israel and Iran.
Speaking to a US broadcaster, Trump however stressed that the US wasn't involved "at this moment".
Israel initially launched an attack on Iranian nuclear infrastructure and other targets on Friday.