The German service union Verdi has called a strike of Lufthansa employees from 4 a.m. on Tuesday to 7:10 a.m. on Wednesday.
Major international airports in the German cities of Frankfurt, Munich, Hamburg, Berlin, Stuttgart and Düsseldorf are set to be affected, as is Cologne-Bonn.
Around 900 out of 1,000 scheduled flights have been canceled, affecting around 100,000 passengers, according to Lufthansa.
The union has been involved in an ongoing dispute with the airline, calling for 12.5% pay rises and a one-off group-wide inflation bonus for 25,000 Lufthansa employees
Lufthansa last week increased its offer to a 10% pay rise.